Comprehensive list of Tamil movies released in 2000. Click on movie names for more details.
| Movie Name | Director | Cast |
|---|---|---|
| Kadhal Rojave | K. R. | George, Pooja Kumar, Sarath Babu |
| Kannukkul Nilavu | Fazil | Vijay, Shalini, Kaveri, Raghuvaran |
| Thirunelveli | Bharathi Kannan | Prabhu, Roja, Karan, Udhaya, Sithara, Vindhya |
| Vanathai Pola | Vikraman | Vijayakanth, Prabhu Deva, Livingston, Meena, Kausalya, Anju Aravind |
| Eazhaiyin Sirippil | K. Subhash | Prabhu Deva, Roja, Kausalya, Suvalakshmi |
| Good Luck | Manoj Bhatnagar | Prashanth, Riya Sen, Raghuvaran, Suhasini |
| Annai | Manobala | Bhanupriya, Nassar, Ramesh Khanna, Manobala |
| Hey Ram | Kamal Haasan | Kamal Haasan, Atul Kulkarni, Shahrukh Khan, Rani Mukerji, Hema Malini, Vasundhara Das |
| Sudhandhiram | Raj Kapoor | Arjun, Rambha, Ranjith, Raghuvaran, Radhika |
| Thai Poranthachu | Kalaimani | Prabhu, Kausalya, Karthik Muthuraman |
| Mugavaree | V. Z. Durai | Ajith Kumar, Jyothika, Suchindra, Raghuvaran, K. Viswanath |
| Kakkai Siraginilae | P. Vasu | R. Parthiban, Preetha Vijayakumar, Lakshmi, K. Viswanath |
| Alaipayuthey | Mani Ratnam | R. Madhavan, Shalini |
| Rajakaali Amman | Rama Narayanan | Ramya Krishnan, Kausalya, Karan |
| Sandhitha Velai | Ravichandran | Karthik Muthuraman, Roja, Kausalya |
| Vallarasu | N. Maharajan | Vijayakanth, Devayani |
| James Pandu | Selva | R. Parthiban, Prabhu Deva, Kausalya, Renu |
| Veeranadai | Seeman | Sathyaraj, Arun Pandian, Kushboo, Uma |
| Athey Manithan | K. Rajeswar | Livingston, Maheswari, Lakshmi |
| Kandukondain Kandukondain | Rajiv Menon | Mammooty, Ajith Kumar, Tabu, Aishwarya Rai, Abbas |
| Kandha Kadamba Kathir Vela | Rama Narayanan | Prabhu, S. Ve. Sekhar, Roja, Nirosha, Vivek, Vadivelu |
| Kushi | S. J. Suryaah | Vijay, Jyothika, Mumtaj |
| Kannan Varuvaan | Sundar C | Karthik Muthuraman, Divya Unni, Mantra, Goundamani |
| Unnai Kodu Ennai Tharuven | Kavi Kalidas | Ajith Kumar, Simran |
| Magalirkkaga | Indian | Kushboo, Ambika, Vindhya, Ranjith |
| Karisakattu Poove | Kasthuri Raja | Napoleon, Kushboo, Vineeth, Ravali |
| Appu | Vasanth | Prashanth, Devayani, Vignesh, Kaveri |
| Ennamma Kannu | Sakthi Chidambaram | Sathyaraj, Devayani |
| Vetri Kodi Kattu | Cheran | R. Parthiban, Murali, Meena, Malavika |
| Pennin Manathai Thottu | Ezhil | Prabhu Deva, Sarath Kumar, Jaya Seal |
| Aatha Kann Thirandha | Rajesh Raghunath | Shruti |
| Koodi Vazhndhal Kodi Nanmai | V. Sekhar | Nassar, Karan, Kushboo, Roja, Vadivelu, Vivek |
| Kuberan | Rama Narayanan | Karthik Muthuraman, Kausalya, Mantra |
| Kann Thirandhu Paaramma | L. C. Selva | Sangita, Ranjith |
| Simmasanam | Eshwar | Vijayakanth, Kushboo, Mantra, Radhika Chowdry |
| Doubles | Pandiarajan | Prabhu Deva, Meena, Pandiarajan, Sangeetha |
| Independence Day | A. R. Ramesh | Arun Pandian, Roja, Sai Kumar |
| Parthen Rasithen | Saran | Prashanth, Simran, Laila, Raghuvaran, Raghava Lawrence |
| Kannal Paesava | Rajkhanna | Arun Vijay, Suvalakshmi, Goundamani |
| Maayi | Surya Prakash | Sarath Kumar, Meena, Suvalakshmi |
| Bharathi | Gnana Rajasekaran | Sayaji Shinde, Devayani |
| Chinna Chinna Kannilae | Amirjan | Prakash Raj, Kushboo, Nassar |
| Krodham 2 | Prem | Prem, Radhika Chowdry, Kushboo |
| Sabhash | K. Subaash | R. Parthiban, Ranjith, Divya Unni |
| Unnai Kann Theduthey | Sundar C. | Sathyaraj, Kushboo, Ravali |
| Budget Padmanabhan | T. P. Gajendran | Prabhu, Ramya Krishnan, Mumtaj, Karan |
| Ninaivellam Nee | Jayaram V. Esthava | Livingston, Anju Aravind |
| Rhythm | Vasanth | Arjun, Meena, Jyothika, Ramesh Aravind |
| Ilayavan | T. Babu | Sathyan, Kausalya |
| Karuvellam Pookal | Poomani | Nassar, Radhika |
| Uyirile Kalanthathu | K. R. Jaya | Suriya, Jyothika, Raghuvaran |
| Kannukku Kannaga | S. Dayalan | Murali, Devayani, Raja, Vindhya |
| Palayathu Amman | Rama Narayanan | Meena, Ramki, Divya Unni |
| Priyamanavale | K. Selva Bharathy | Vijay, Simran, Radhika Chowdry |
| Thenali | K. S. Ravikumar | Kamal Haasan, Jyothika, Jayaram, Devayani |
| Vaanavil | Manoj Kumar | Arjun, Abhirami, Uma |
| Seenu | P. Vasu | Karthik Muthuraman, Malavika, P. Vasu |
| Anbudan | Indra Kumar | Arun Vijay, Rambha, Meena |
| Vanna Thamizh Pattu | P. Vasu | Prabhu, Vaijayanthi, Rachana Banerjee |
| En Sakiyae | Raviraja | Prabhusekhar, Divya, Devaraj |
| Penngal | Raj Marudhu | Jai Akash, Divyasri |
| Manasu | Abdul Rahman | Shakti, Oviya, Sanjeev Kumar |
| Aval Paavam | M. K. Arundhava Raja | Prabhukanth, Ritika |
| Ennavale | Suresh | R. Madhavan, Sneha |
| Manuneedhi | Thambi Ramaiah | Murali, Prathyusha |
| Nee Endhan Vaanam | R. K. Suresh | Vignesh, Reshma |